Jori, A., Caccia, S.: Distribution of amphetamine and its hydroxylated metabolites in various areas of the rat brain. Honecker, H., Coper, H.: Kinetics and metabolism of amphetamine in the brain of rat of different ages. O.: Effects of the d and l isomers of amphetamine on uptake, release and catabolism of norepinephrine, dopamine and 5-hydroxytryptamine in several regions of rat brain. Häggendal, J., Hamberger, B.: Quantitative in vitro studies on noradrenaline uptake and its inhibition by amphetamine, desipramine and chlorpromazine. R.: The action of some amines related to adrenaline, cyclohexamines. Effects of drugs on the disposition and metabolism of 3H norepinephrine and 3H dopamine. L.: Regional studies of catecholamine in the rat brain. Glowinski, J., Axelrod, J.: Effects of drugs on the uptake, release and metabolism of 3H norepinephrine in the rat brain. A.: A comparison of the capacities of isomers of amphetamine, deoxypipradol and methylphenidate to inhibit the uptake of tritiated catecholamines into rat cerebral cortex slices, synaptosomal preparations of rat cerebral cortex, hypothalamus and striatum and into adrenergic nerves of rabbit aorta. H.: Catecholamine uptake by synaptosomes in homogenates of rat brain. 17, 521–531 (1965)Ĭosta, E., Garattini, S.: International symposium on amphetamine and related compounds. ![]() 31, 2187–2196 (1937)Ĭarlsson, A., Lindquist, M., Dahlstrom, A., Fuxe, K., Masuoka, D.: Effects of the amphetamine group on intraneuronal brain amines in vivo and in vitro. 189, 110–118 (1974)īlaschko, H., Richter, D., Schlossman, H.: The oxidation of adrenaline and other amines. O.: The importance of neuronal uptake of amines for amphetamine induced release of 3H norepinephrine from isolated brain tissue. The observed differences between d- and l-amphetamine kinetics in brain areas of isolated and aggregated rats may explain certain aspects of the pharmacological activities of these drugs.Īzzaro, A. The half-lives of d-amphetamine in different brain areas were, however, shorter than those of the l-isomer. In other brain regions both d- and l-amphetamine were eliminated as a monoexponential function. ![]() d-Amphetamine was eliminated from the striatum and hippocampus as a biexponential function, and l-amphetamine elimination was biphasic only in the striatum. In aggregated rats certain differences were observed. In whole brains of aggregated rats the disappearance curves were biexponential (half-lives: d-amphetamine, 0.9☐.1 and 2.3☐.2 h l-amphetamine, 0.7☐.1 and 2.3☐.1 h).įor the brain areas of isolated rats, the elimination curves of amphetamines were monoexponential and the half-lives of d- and l-amphetamine were almost identical. The half-lives of d- and l-amphetamine in whole brain were 1.2☐.1 and 1.3☐.1 h, respectively. In isolated rats, the disappearance curves of the labelled amphetamines were monoexponential. injection of 15 mg/kg of d- or l- 14C-amphetamine was followed by the determination of drug concentrations in the cerebral cortex, hypothalamus, medulla oblongata-pons, cerebellum, striatum, hippocampus, and the whole brain after solvent extraction. The kinetics of d- and l-amphetamine were investigated in isolated and aggregated male rats.
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